Linked Life Data

19596194

Source:http://linkedlifedata.com/resource/pubmed/id/19596194

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2009-7-29
pubmed:abstractText
We investigated proinflammatory cytokine TNFalpha production inhibitors in order to develop novel anti-inflammatory agents. According to the results, we found that 17, a pyrrole derivative possessing a tetrahydropyridine group at the beta-position, showed potent inhibitory activity in vitro (inhibition of lipopolysaccharide (LPS) induced TNFalpha production in human whole blood, IC(50)=1.86 microM) and in vivo (inhibition of LPS induced TNFalpha production in mice, ID(50)=5.98 mg/kg).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1464-3405
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4607-10
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 1.
pubmed:affiliation
Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co, Ltd, 1-16-13 Kitakasai, Tokyo 134-8630, Japan. nakao.akira.g5@daiichisankyo.co.jp
pubmed:publicationType
Journal Article