| pubmed-article:19596051 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C0920397 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1879648 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:19596051 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:19596051 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19596051 | pubmed:dateCreated | 2009-9-18 | lld:pubmed |
| pubmed-article:19596051 | pubmed:abstractText | Previous data demonstrate that L-type voltage-gated calcium channel (VGCC) blockers, which bind to alpha(1) subunits of VGCC to suppress Ca(2+) entry into cells, inhibit the development of psychological dependence on drugs of abuse, suggesting the upregulation of L-type VGCC in the development of psychological dependence. However, there are few available data on changes of the auxiliary subunit alpha(2)/delta modifying L-type VGCC under such conditions. We therefore investigated here the role of alpha(2)/delta subunits of VGCCs in the brain of mouse after repeated treatment with morphine. The treatment with morphine increased alpha(2)/delta subunit expression in the frontal cortex and the limbic forebrain of mice showing rewarding effect and sensitization to hyperlocomotion by morphine. The morphine-induced behavioral sensitization and place preference were also suppressed by gabapentin, which binds to an exofacial epitope of the alpha(2)/delta auxiliary subunits of VGCCs. These findings indicate that the upregulation of alpha(2)/delta subunit as well as alpha(1) subunits of VGCC in the frontal cortex and the limbic forebrain plays a critical role in development of morphine-induced rewarding effect and behavioral sensitization following neuronal plasticity. | lld:pubmed |
| pubmed-article:19596051 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19596051 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19596051 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19596051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19596051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19596051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19596051 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19596051 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19596051 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19596051 | pubmed:issn | 1873-7544 | lld:pubmed |
| pubmed-article:19596051 | pubmed:author | pubmed-author:KurokawaKK | lld:pubmed |
| pubmed-article:19596051 | pubmed:author | pubmed-author:OhkumaSS | lld:pubmed |
| pubmed-article:19596051 | pubmed:author | pubmed-author:ShibasakiMM | lld:pubmed |
| pubmed-article:19596051 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19596051 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:19596051 | pubmed:volume | 163 | lld:pubmed |
| pubmed-article:19596051 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19596051 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19596051 | pubmed:pagination | 731-4 | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
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| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:meshHeading | pubmed-meshheading:19596051... | lld:pubmed |
| pubmed-article:19596051 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19596051 | pubmed:articleTitle | Role of alpha2/delta subunit in the development of morphine-induced rewarding effect and behavioral sensitization. | lld:pubmed |
| pubmed-article:19596051 | pubmed:affiliation | Department of Pharmacology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701-0192, Japan. | lld:pubmed |
| pubmed-article:19596051 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19596051 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| entrez-gene:319734 | entrezgene:pubmed | pubmed-article:19596051 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19596051 | lld:entrezgene |
