|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
1977-9-29
|
|
pubmed:abstractText |
Carp parvalbumin has been shown to activate rat brain phosphodiesterase in a Ca2+-dependent manner. The concentration of Ca2+ required for half-maximal stimulation is 1.4 X 10(-7) M, whereas rat testis Ca2+-dependent regulator (CDR) of phosphodiesterase required 1.2 X 10(-6) M Ca2+. The difference in the slopes of the two curves demonstrated that the activation induced by parvalbumin was not the result of a small contamination by CDR. In addition, it has been shown that Ca2+ binding to parvalbumin parallels its activation of phosphodiesterase. These data suggest that Ca2+ must bind to a single specific metal binding site before phosphodiesterase can be fully activated.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
25
|
|
pubmed:volume |
252
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5609-11
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:195956-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:195956-Animals,
pubmed-meshheading:195956-Binding Sites,
pubmed-meshheading:195956-Brain,
pubmed-meshheading:195956-Calcium,
pubmed-meshheading:195956-Enzyme Activation,
pubmed-meshheading:195956-Fishes,
pubmed-meshheading:195956-Kinetics,
pubmed-meshheading:195956-Male,
pubmed-meshheading:195956-Muscle Proteins,
pubmed-meshheading:195956-Muscles,
pubmed-meshheading:195956-Parvalbumins,
pubmed-meshheading:195956-Phosphoric Diester Hydrolases,
pubmed-meshheading:195956-Proteins,
pubmed-meshheading:195956-Rats,
pubmed-meshheading:195956-Testis
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
