|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0016163,
umls-concept:C0021798,
umls-concept:C0023449,
umls-concept:C0162789,
umls-concept:C0205210,
umls-concept:C0215508,
umls-concept:C0392747,
umls-concept:C0796520,
umls-concept:C1335654,
umls-concept:C1446409,
umls-concept:C1524062,
umls-concept:C1705326,
umls-concept:C1707513,
umls-concept:C2347946
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2009-10-14
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|
pubmed:abstractText |
TEL/AML1 (ETV6/RUNX1) fusion resulting from the translocation t(12;21)(p13;q22) constitutes the most common chimeric fusion gene in initial childhood B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) (19-27%) and has been associated with good prognosis. Three secondary aberrations in TEL/AML1 positive ALL have been suspected to negatively influence outcome: deletion of the second TEL allele (T), gain of the second AML1 allele (A) and duplication of the derivative chromosome 21 (der(21), TA). Many studies have explored such aberrations in initial disease, while only few reports have investigated them in relapses.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1600-0609
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
83
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
420-32
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|
pubmed:meshHeading |
pubmed-meshheading:19594616-Child,
pubmed-meshheading:19594616-Child, Preschool,
pubmed-meshheading:19594616-Chromosomes, Human, Pair 12,
pubmed-meshheading:19594616-Chromosomes, Human, Pair 21,
pubmed-meshheading:19594616-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:19594616-Female,
pubmed-meshheading:19594616-Gene Dosage,
pubmed-meshheading:19594616-Humans,
pubmed-meshheading:19594616-In Situ Hybridization, Fluorescence,
pubmed-meshheading:19594616-Interphase,
pubmed-meshheading:19594616-Male,
pubmed-meshheading:19594616-Mutation,
pubmed-meshheading:19594616-Oncogene Proteins, Fusion,
pubmed-meshheading:19594616-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19594616-Recurrence,
pubmed-meshheading:19594616-Translocation, Genetic
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Interphase FISH on TEL/AML1 positive acute lymphoblastic leukemia relapses--analysis of clinical relevance of additional TEL and AML1 copy number changes.
|
|
pubmed:affiliation |
Department of Pediatric Oncology and Hematology, Otto-Heubner-Center for Pediatrics, Charité Campus Virchow-Klinikum, Berlin D-13353, Germany.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
