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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-4-19
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pubmed:abstractText |
In the present study, we evaluated the ability of 4-hydroxytamoxifen (OHT) and epidermal growth factor (EGF) to regulate homotypic adhesion in MCF7 breast cancer cells. Our results demonstrate that OHT and EGF activate the E-cadherin promoter, increase E-cadherin mRNA and protein expression and enhance homotypic aggregation of MCF7 cells. Interestingly, an ERalpha and EGFR cross-talk is involved in the E-cadherin expression by OHT and EGF, as demonstrated by knocking down either receptor. On the basis of our findings, the well-established cross-talk between ERalpha and EGFR could be extended to the modulation of E-cadherin expression by OHT and EGF. Thus, the potential ability of tamoxifen to induce cell-cell aggregation may contribute to the biologic response of pharmacologic intervention in patients with breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1573-7217
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-89
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pubmed:meshHeading |
pubmed-meshheading:19593637-Antineoplastic Agents, Hormonal,
pubmed-meshheading:19593637-Blotting, Western,
pubmed-meshheading:19593637-Breast Neoplasms,
pubmed-meshheading:19593637-Cadherins,
pubmed-meshheading:19593637-Cell Adhesion,
pubmed-meshheading:19593637-Cell Aggregation,
pubmed-meshheading:19593637-Cell Line, Tumor,
pubmed-meshheading:19593637-Epidermal Growth Factor,
pubmed-meshheading:19593637-Estrogen Receptor alpha,
pubmed-meshheading:19593637-Female,
pubmed-meshheading:19593637-Gene Expression,
pubmed-meshheading:19593637-Gene Expression Profiling,
pubmed-meshheading:19593637-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:19593637-Humans,
pubmed-meshheading:19593637-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19593637-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19593637-Receptor Cross-Talk,
pubmed-meshheading:19593637-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19593637-Signal Transduction,
pubmed-meshheading:19593637-Tamoxifen,
pubmed-meshheading:19593637-Transcriptional Activation,
pubmed-meshheading:19593637-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.
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pubmed:affiliation |
Department Cellular Biology, University of Calabria, Cosenza, Arcavacata-Rende (CS), 87030, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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