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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-10-1
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pubmed:abstractText |
Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may attenuate these pathogenic processes. Activation of AMP-activated protein kinase (AMPK) has been reported to reduce intracellular reactive oxygen species (ROS) levels. The thioredoxin (Trx) system is a major antioxidant system. In this study, we investigated the mechanisms involved in the AMPK-mediated regulation of Trx expression and the reduction of intracellular ROS levels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AICA ribonucleotide,
http://linkedlifedata.com/resource/pubmed/chemical/AMP-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Aminoimidazole Carboxamide,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Thioredoxins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:ChenLiL,
pubmed-author:CoselliJoseph SJS,
pubmed-author:HouXiaoyangX,
pubmed-author:LeMaireScott ASA,
pubmed-author:LiXiao-NanXN,
pubmed-author:ShenYing HYH,
pubmed-author:SongJunJ,
pubmed-author:WangXing LiXL,
pubmed-author:ZhangChengC,
pubmed-author:ZhangLinL,
pubmed-author:ZhangYunY
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2246-57
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pubmed:dateRevised |
2010-10-4
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pubmed:meshHeading |
pubmed-meshheading:19592618-AMP-Activated Protein Kinases,
pubmed-meshheading:19592618-Aminoimidazole Carboxamide,
pubmed-meshheading:19592618-Animals,
pubmed-meshheading:19592618-Aorta,
pubmed-meshheading:19592618-Apolipoproteins E,
pubmed-meshheading:19592618-DNA Primers,
pubmed-meshheading:19592618-Endothelium, Vascular,
pubmed-meshheading:19592618-Fatty Acids,
pubmed-meshheading:19592618-Forkhead Transcription Factors,
pubmed-meshheading:19592618-Humans,
pubmed-meshheading:19592618-Male,
pubmed-meshheading:19592618-Mice,
pubmed-meshheading:19592618-Mice, Knockout,
pubmed-meshheading:19592618-Palmitic Acid,
pubmed-meshheading:19592618-Plasmids,
pubmed-meshheading:19592618-RNA, Messenger,
pubmed-meshheading:19592618-RNA, Small Interfering,
pubmed-meshheading:19592618-Reactive Oxygen Species,
pubmed-meshheading:19592618-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19592618-Ribonucleotides,
pubmed-meshheading:19592618-Thioredoxins,
pubmed-meshheading:19592618-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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