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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-20
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pubmed:abstractText |
Arterial injury induces smooth muscle cell (SMC) proliferation, migration, and intimal accumulation of cells and extracellular matrix. These processes are regulated by the administration of the glycosaminoglycans heparin and heparan sulfate, but little is known about the role of endogenous heparan sulfate proteoglycans in the vessel wall. We investigated the response to carotid injury of syndecan-1-null mice to assess the function of one of a conserved family of transmembrane heparan and chondroitin sulfate proteoglycans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-sis,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Platelet-Derived Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Sdc1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Syndecan-1,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/platelet-derived growth factor BB
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1356-62
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:19592464-Animals,
pubmed-meshheading:19592464-Carotid Artery, Common,
pubmed-meshheading:19592464-Carotid Artery Injuries,
pubmed-meshheading:19592464-Cell Movement,
pubmed-meshheading:19592464-Cell Proliferation,
pubmed-meshheading:19592464-Cells, Cultured,
pubmed-meshheading:19592464-DNA Replication,
pubmed-meshheading:19592464-Disease Models, Animal,
pubmed-meshheading:19592464-Epidermal Growth Factor,
pubmed-meshheading:19592464-Fibroblast Growth Factor 2,
pubmed-meshheading:19592464-Hyperplasia,
pubmed-meshheading:19592464-Mice,
pubmed-meshheading:19592464-Mice, Inbred C57BL,
pubmed-meshheading:19592464-Mice, Knockout,
pubmed-meshheading:19592464-Muscle, Smooth, Vascular,
pubmed-meshheading:19592464-Platelet-Derived Growth Factor,
pubmed-meshheading:19592464-Proto-Oncogene Proteins c-sis,
pubmed-meshheading:19592464-Receptor, Platelet-Derived Growth Factor beta,
pubmed-meshheading:19592464-Signal Transduction,
pubmed-meshheading:19592464-Syndecan-1,
pubmed-meshheading:19592464-Thrombin,
pubmed-meshheading:19592464-Time Factors,
pubmed-meshheading:19592464-Tunica Intima
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pubmed:year |
2009
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pubmed:articleTitle |
Syndecan-1: an inhibitor of arterial smooth muscle cell growth and intimal hyperplasia.
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pubmed:affiliation |
Department of Surgery and Center for Cardiovascular Biology, University of Washington, Seattle, WA 98195-6410, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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