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rdf:type |
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lifeskim:mentions |
umls-concept:C0022646,
umls-concept:C0023823,
umls-concept:C0024432,
umls-concept:C0025517,
umls-concept:C0026809,
umls-concept:C0038734,
umls-concept:C0175677,
umls-concept:C0205263,
umls-concept:C0242606,
umls-concept:C0871261,
umls-concept:C1563937,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-22
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pubmed:abstractText |
Strengthening the macrophage glutathione redox buffer reduces macrophage content and decreases the severity of atherosclerotic lesions in LDL receptor-deficient (LDLR(-/-)) mice, but the underlying mechanisms were not clear. This study examined the effect of metabolic stress on the thiol redox state, chemotactic activity in vivo, and the recruitment of macrophages into atherosclerotic lesions and kidneys of LDL-R(-/-) mice in response to mild, moderate, and severe metabolic stress.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1779-86
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pubmed:dateRevised |
2011-8-31
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pubmed:meshHeading |
pubmed-meshheading:19592463-Analysis of Variance,
pubmed-meshheading:19592463-Animals,
pubmed-meshheading:19592463-Atherosclerosis,
pubmed-meshheading:19592463-Blood Chemical Analysis,
pubmed-meshheading:19592463-Cells, Cultured,
pubmed-meshheading:19592463-Chemotaxis,
pubmed-meshheading:19592463-Diabetes Mellitus, Experimental,
pubmed-meshheading:19592463-Disease Models, Animal,
pubmed-meshheading:19592463-Female,
pubmed-meshheading:19592463-Hypercholesterolemia,
pubmed-meshheading:19592463-Kidney Diseases,
pubmed-meshheading:19592463-Macrophages, Peritoneal,
pubmed-meshheading:19592463-Mice,
pubmed-meshheading:19592463-Mice, Inbred C57BL,
pubmed-meshheading:19592463-Mice, Transgenic,
pubmed-meshheading:19592463-Oxidation-Reduction,
pubmed-meshheading:19592463-Oxidative Stress,
pubmed-meshheading:19592463-Probability,
pubmed-meshheading:19592463-Random Allocation,
pubmed-meshheading:19592463-Receptors, LDL,
pubmed-meshheading:19592463-Streptozocin,
pubmed-meshheading:19592463-Sulfhydryl Compounds,
pubmed-meshheading:19592463-Urinalysis
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pubmed:year |
2009
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pubmed:articleTitle |
Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice.
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pubmed:affiliation |
Office of the Dean, School of Health Professions, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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