| pubmed-article:1959240 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1959240 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:1959240 | lifeskim:mentions | umls-concept:C0040300 | lld:lifeskim |
| pubmed-article:1959240 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1959240 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:1959240 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:1959240 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1959240 | pubmed:dateCreated | 1992-1-3 | lld:pubmed |
| pubmed-article:1959240 | pubmed:abstractText | A comparative study was performed to examine the lethal effects of several cytokines injected into mice sensitized with actinomycin D (Act-D). Consistent with published data, human tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) (0.2-5 micrograms) caused the death of the animals within 8-12 hr after injection. Human interleukin-6 (IL-6) and interleukin-8 (IL-8) (0.6-6 micrograms) known to be induced by TNF-alpha did not show any lethal effects, indicating that TNF-alpha-associated lethality is not mediated by IL-6 or IL-8. Human tumor necrosis factor-beta (TNF-beta) (also called lymphotoxin), which shares structural and functional properties with TNF-alpha, was as potent as TNF-alpha in its lethal effects. Murine interferon-gamma (IFN-gamma) (0.04-5 micrograms) was also tested and showed no lethal effects in this model. In addition, a synthetic peptide corresponding to amino acid residues 163-171 of IL-1 beta, and which has been shown to lack the inflammatory effects of IL-1 beta, also caused no lethality among Act-D sensitized mice. The pretreatment of mice with IL-6, IL-8, or IFN-gamma had no protective effects on TNF-alpha or IL-1 beta-induced lethality in contrast to the protection observed by a pretreatment with TNF-alpha/IL-1 beta themselves or with endotoxin. Histopathologic data showed that severe tissue injury in vital organs is associated with the rapid lethality among sensitized mice. | lld:pubmed |
| pubmed-article:1959240 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1959240 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1959240 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1959240 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1959240 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:BoraschiDD | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:MatsushimaKK | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:LamvikJJ | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:AardenLL | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:WaageAA | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:ShalabyM RMR | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:HaugenO AOA | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:HalgunsetJJ | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:AarsetHH | lld:pubmed |
| pubmed-article:1959240 | pubmed:author | pubmed-author:KvithyllHH | lld:pubmed |
| pubmed-article:1959240 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1959240 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:1959240 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1959240 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:1959240 | pubmed:pagination | 69-82 | lld:pubmed |
| pubmed-article:1959240 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
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| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:meshHeading | pubmed-meshheading:1959240-... | lld:pubmed |
| pubmed-article:1959240 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1959240 | pubmed:articleTitle | Cytokine-associated tissue injury and lethality in mice: a comparative study. | lld:pubmed |
| pubmed-article:1959240 | pubmed:affiliation | Institute of Cancer Research, University of Trondheim, Norway. | lld:pubmed |
| pubmed-article:1959240 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1959240 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1959240 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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