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pubmed-article:19589538pubmed:abstractTextChronic allograft nephropathy (CAN) is a major cause of late allograft loss. Recent evidences suggest that Rho and its downstream effector ROCK may be greatly involved in the progression of renal fibrosis. Inhibition of Rho/ROCK pathway might interact with the inflammatory process in the renal interstitium, and antagonize the process of epithelial-to-mesenchymal transition (EMT). We hypothesized that Y-27632 could inhibit the chronic inflammatory process and prevent the progression of CAN.lld:pubmed
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pubmed-article:19589538pubmed:articleTitleTherapeutic effect of Y-27632 on chronic allograft nephropathy in rats.lld:pubmed
pubmed-article:19589538pubmed:affiliationNanjing Medical University First Affiliated Hospital, Jiangsu, China.lld:pubmed
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