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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-10-19
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pubmed:abstractText |
Chronic allograft nephropathy (CAN) is a major cause of late allograft loss. Recent evidences suggest that Rho and its downstream effector ROCK may be greatly involved in the progression of renal fibrosis. Inhibition of Rho/ROCK pathway might interact with the inflammatory process in the renal interstitium, and antagonize the process of epithelial-to-mesenchymal transition (EMT). We hypothesized that Y-27632 could inhibit the chronic inflammatory process and prevent the progression of CAN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/Y 27632,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-8673
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e117-27
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pubmed:meshHeading |
pubmed-meshheading:19589538-Actins,
pubmed-meshheading:19589538-Amides,
pubmed-meshheading:19589538-Animals,
pubmed-meshheading:19589538-Chemokine CCL2,
pubmed-meshheading:19589538-Chemokine CCL5,
pubmed-meshheading:19589538-Chronic Disease,
pubmed-meshheading:19589538-Delayed Graft Function,
pubmed-meshheading:19589538-Enzyme Inhibitors,
pubmed-meshheading:19589538-Fibrosis,
pubmed-meshheading:19589538-Kidney Transplantation,
pubmed-meshheading:19589538-Male,
pubmed-meshheading:19589538-NF-kappa B,
pubmed-meshheading:19589538-Nephritis,
pubmed-meshheading:19589538-Pyridines,
pubmed-meshheading:19589538-Rats,
pubmed-meshheading:19589538-Rats, Inbred F344,
pubmed-meshheading:19589538-Rats, Inbred Lew,
pubmed-meshheading:19589538-Transforming Growth Factor beta1,
pubmed-meshheading:19589538-Transplantation, Homologous,
pubmed-meshheading:19589538-rho-Associated Kinases
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pubmed:year |
2009
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pubmed:articleTitle |
Therapeutic effect of Y-27632 on chronic allograft nephropathy in rats.
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pubmed:affiliation |
Nanjing Medical University First Affiliated Hospital, Jiangsu, China.
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pubmed:publicationType |
Journal Article
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