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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-9-14
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pubmed:abstractText |
Several clinical and genetic studies have focused on the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of various mental disorders. Recent lines of evidence regarding the network hypothesis of treatment outcome point towards the involvement of BDNF variants in the pharmacologic response in mood disorders (MD). Furthermore, there is strong evidence of a role for the serotonergic system in the pathophysiology and treatment of OCD, and upregulation of BDNF has been observed with various classes of antidepressants, including selective serotonin reuptake inhibitors (SSRI). Thus, we hypothesized that the BDNF gene might also be associated with treatment outcome in OCD.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-2402
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
674-80
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pubmed:meshHeading |
pubmed-meshheading:19589503-Adolescent,
pubmed-meshheading:19589503-Adult,
pubmed-meshheading:19589503-Aged,
pubmed-meshheading:19589503-Antidepressive Agents,
pubmed-meshheading:19589503-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:19589503-Dose-Response Relationship, Drug,
pubmed-meshheading:19589503-Female,
pubmed-meshheading:19589503-Follow-Up Studies,
pubmed-meshheading:19589503-Gene Frequency,
pubmed-meshheading:19589503-Genetic Predisposition to Disease,
pubmed-meshheading:19589503-Haplotypes,
pubmed-meshheading:19589503-Humans,
pubmed-meshheading:19589503-Male,
pubmed-meshheading:19589503-Middle Aged,
pubmed-meshheading:19589503-Obsessive-Compulsive Disorder,
pubmed-meshheading:19589503-Odds Ratio,
pubmed-meshheading:19589503-Polymorphism, Single Nucleotide,
pubmed-meshheading:19589503-Psychiatric Status Rating Scales,
pubmed-meshheading:19589503-Severity of Illness Index,
pubmed-meshheading:19589503-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder.
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pubmed:affiliation |
OCD Clinical and Research Unit, Instituto de Salud Carlos III, Department of Psychiatry, Bellvitge University Hospital, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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