Source:http://linkedlifedata.com/resource/pubmed/id/19589485
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2009-7-10
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| pubmed:abstractText |
The association of iron overload with complications of allogeneic hematopoietic stem cell transplantation (HSCT) has been suggested in previous studies. Because hepcidin plays a central role in the regulation of iron homeostasis, we analyzed the association between pretransplant serum hepcidin-25 levels and early infectious complications after allogeneic HSCT. We studied 55 consecutive adult patients with a median age of 47 years (range: 20-64 years) who underwent allogeneic HSCT for hematologic malignancies at our institution. Thirty-two patients had myelogenous malignancies; the remaining 23 had lymphogenous malignancies. The median pretransplant serum hepcidin level of patients in the study was 21.6 ng/mL (range: 1.4-371 ng/mL), which was comparable to that of healthy volunteers (median: 19.1 ng/mL [range: 2.3-37 ng/mL]; n = 17). When cumulative incidences of documented bacterial and cytomegalovirus (CMV) infections at day 100 were compared according to pretransplant hepcidin-25 levels, the incidence of bacterial, but not CMV, infection, was significantly higher in the high-hepcidin group (> or = 50 ng/mL; n = 17) than in the low-hepcidin group (<50 ng/mL; n = 38) (65% [95% confidence interval, 38%-82%] versus 11% [3%-23%]; P < .001). This finding was confirmed by multivariate Cox analysis adjusted for confounders, including pretransplant ferritin and C-reactive protein (CRP) levels. No fungal infection was documented in either group. These results suggest that the pretransplant serum hepcidin-25 level may be a useful marker for predicting the risk of early bacterial complications after allogeneic HSCT. Larger prospective studies are, however, warranted to confirm our findings.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1523-6536
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| pubmed:author |
pubmed-author:IchinoheTatsuoT,
pubmed-author:IshikawaTakayukiT,
pubmed-author:KandaJunyaJ,
pubmed-author:KawabataHiroshiH,
pubmed-author:KondoTadakazuT,
pubmed-author:MatsuoKeitaroK,
pubmed-author:MizumotoChisakiC,
pubmed-author:TomosugiNaohisaN,
pubmed-author:TsuchidaHideyukiH,
pubmed-author:UchiyamaTakashiT,
pubmed-author:YamashitaKouheiK
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
956-62
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| pubmed:meshHeading |
pubmed-meshheading:19589485-Adult,
pubmed-meshheading:19589485-Antimicrobial Cationic Peptides,
pubmed-meshheading:19589485-Bacterial Infections,
pubmed-meshheading:19589485-Biological Markers,
pubmed-meshheading:19589485-Cytomegalovirus Infections,
pubmed-meshheading:19589485-Female,
pubmed-meshheading:19589485-Hematologic Neoplasms,
pubmed-meshheading:19589485-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19589485-Humans,
pubmed-meshheading:19589485-Iron Overload,
pubmed-meshheading:19589485-Male,
pubmed-meshheading:19589485-Middle Aged,
pubmed-meshheading:19589485-Opportunistic Infections,
pubmed-meshheading:19589485-Predictive Value of Tests,
pubmed-meshheading:19589485-Risk,
pubmed-meshheading:19589485-Transplantation, Homologous,
pubmed-meshheading:19589485-Young Adult
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| pubmed:year |
2009
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| pubmed:articleTitle |
Clinical significance of serum hepcidin levels on early infectious complications in allogeneic hematopoietic stem cell transplantation.
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| pubmed:affiliation |
Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. jkanda16@kuhp.kyoto-u.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|