Source:http://linkedlifedata.com/resource/pubmed/id/19589337
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-9-23
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| pubmed:abstractText |
Zn(II)-curcumin, a mononuclear (1:1) zinc complex of curcumin was synthesized and examined for its antiulcer activities against pylorus-ligature-induced gastric ulcer in rats. The structure of Zn(II)-curcumin was identified by elemental analysis, NMR and TG-DTA analysis. It was found that a zinc atom was coordinated through the keto-enol group of curcumin along with one acetate group and one water molecule. Zn(II)-curcumin (12, 24 and 48 mg/kg) dose-dependently blocked gastric lesions, significantly reduced gastric volume, free acidity, total acidity and pepsin, compared with control group (P<0.001) and curcumin alone (24 mg/kg, P<0.05). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis showed that Zn(II)-curcumin markedly inhibited the induction of nuclear factor-kappa B (NF-kappaB), transforming growth factor beta(1) (TGF-beta(1)) and interleukin-8 (IL-8), compared with control group (P<0.05). These findings suggested that Zn(II)-curcumin prevented pylorus-ligation-induced lesions in rat by inhibiting NF-kappaB activation and the subsequent production of proinflammatory cytokines, indicating a synergistic effect between curcumin and zinc. An acute toxicity study showed that mice treated with SDs of Zn(II)-curcumin (2 g/kg) manifested no abnormal signs.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Curcumin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1872-7786
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
30
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| pubmed:volume |
181
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
316-21
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| pubmed:meshHeading |
pubmed-meshheading:19589337-Animals,
pubmed-meshheading:19589337-Anti-Ulcer Agents,
pubmed-meshheading:19589337-Base Sequence,
pubmed-meshheading:19589337-Curcumin,
pubmed-meshheading:19589337-DNA Primers,
pubmed-meshheading:19589337-Dose-Response Relationship, Drug,
pubmed-meshheading:19589337-Interleukin-8,
pubmed-meshheading:19589337-Magnetic Resonance Spectroscopy,
pubmed-meshheading:19589337-Male,
pubmed-meshheading:19589337-Mice,
pubmed-meshheading:19589337-NF-kappa B,
pubmed-meshheading:19589337-Organometallic Compounds,
pubmed-meshheading:19589337-Pyloric Antrum,
pubmed-meshheading:19589337-Rats,
pubmed-meshheading:19589337-Rats, Sprague-Dawley,
pubmed-meshheading:19589337-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19589337-Stomach Ulcer,
pubmed-meshheading:19589337-Transforming Growth Factor beta
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| pubmed:year |
2009
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| pubmed:articleTitle |
Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats.
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| pubmed:affiliation |
Laboratory of Traditional Chinese Medicine and Marine Drugs, School of Life Sciences, Sun Yat-sen University, No. 135, Xin Guang Xi Road, Guangzhou 510275, China.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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