Linked Life Data

19589199

Source:http://linkedlifedata.com/resource/pubmed/id/19589199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-5-26
pubmed:abstractText
The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2), a major regulator of genes encoding Phase II detoxifying enzymes and antioxidant proteins, is important for protecting cells against oxidative damage. In this work, we report that in the immune-mediated motor neuron injury animal model, expression of Nrf2 and antioxidative enzymes including glutathione S-transferase, nicotinamide adenine dinucleotide phosphate (reduced)-quinone oxidoreductase 1 and heme oxygenase 1 were greatly reduced in motor neurons of spinal cord anterior horn in paralyzed guinea pigs, whereas the antioxidant enzymes in the dorsal horn of paralyzed guinea pigs were generally preserved. Our findings suggest that declined antioxidative capacity may contribute to the damage to motor neurons in the process of immune-mediated motor neuron injury. Although the exact mechanism of immune reactivity and Nrf2-antioxidant response element pathway inactivation remains to be elucidated, inducers of Phase II detoxification enzymes may be an attractive therapeutic target for immune-mediated motor neuron degeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1743-1328
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
460-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Reduced Nrf2 and Phase II enzymes expression in immune-mediated spinal cord motor neuron injury.
pubmed:affiliation
Hebei Province Key Laboratory of Neurology, Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't