Linked Life Data

19587546

Source:http://linkedlifedata.com/resource/pubmed/id/19587546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
2009-7-20
pubmed:abstractText
The cellular state of quiescence is characterized by an exit from the cell cycle that is reversible, that is, upon appropriate stimulation, quiescent cells can re-enter the cell cycle, proliferate and produce progeny. In this way, quiescent cells can be distinguished from cells in an irreversibly arrested state such as senescence or terminal differentiation. The molecular basis for reversible versus irreversible cell cycle arrest is unclear. In a recent study, we demonstrated that the transcriptional regulator Hes1 has a role in maintaining fibroblasts in a reversible quiescent state: overexpression of Hes1 protects fibroblasts against senescence or differentiation, and inhibition of endogenous Hes1 makes quiescent fibroblasts more susceptible to these states. Here we describe the molecular mechanisms by which Hes1 regulates gene expression by modifying histone tails and thus affecting chromatin conformation. We put forward models for how Hes1 is regulated and how it protects quiescent cells from differentiation and senescence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2161-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Fear of commitment: Hes1 protects quiescent fibroblasts from irreversible cellular fates.
pubmed:affiliation
Genentech, 1 DNA way, South San Francisco, CA, USA.
pubmed:publicationType
Journal Article