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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0023448,
umls-concept:C0023449,
umls-concept:C0079419,
umls-concept:C0205210,
umls-concept:C0376249,
umls-concept:C0525037,
umls-concept:C0678214,
umls-concept:C0919524,
umls-concept:C1292758,
umls-concept:C1515926,
umls-concept:C1519302,
umls-concept:C1521725,
umls-concept:C1707455,
umls-concept:C1708726,
umls-concept:C1961102,
umls-concept:C2347946
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-12
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pubmed:abstractText |
Although deletions of cell cycle regulatory gene loci have long been reported in various malignancies, little is known regarding their relevance in pediatric T-cell lymphoblastic lymphoma (T-LBL) and T-cell lymphoblastic leukemia (TALL). The current study focused on loss of heterozygosity (LOH) analyses of the CDKN2A/B (chromosome 9p), ATM (chromosome 11q) and p53 (chromosome 17p) gene loci. Frequencies of LOH were compared in 113 pediatric T-LBL and 125 T-ALL who were treated uniformly according to ALL-BFM strategies. Furthermore, LOH findings were correlated with clinical characteristics and tested for their prognostic relevance. LOH at 9p was detected in 47% of T-LBL and 51% of T-ALL, and was associated with male gender in both. In T-ALL, LOH at 9p was associated with favorable initial treatment response. A tendency for favorable event-free-survival was observed in LOH 9p positive T-LBL. The frequency of LOH at chromosomes 11q and 17p was 5% or less for both diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-10071127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-10477677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-11168496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-11260073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-12529672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-16358311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-16421426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-16738692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-16826225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-17786710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-18285545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-18297521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-18421304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-18618503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-7727766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-8876224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9089742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9166859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9233578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9264370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9658723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19586936-9827931
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDKN2B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-62
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19586936-Adolescent,
pubmed-meshheading:19586936-Cell Cycle Proteins,
pubmed-meshheading:19586936-Child,
pubmed-meshheading:19586936-Cyclin-Dependent Kinase Inhibitor p15,
pubmed-meshheading:19586936-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:19586936-DNA, Neoplasm,
pubmed-meshheading:19586936-DNA-Binding Proteins,
pubmed-meshheading:19586936-Female,
pubmed-meshheading:19586936-Genetic Loci,
pubmed-meshheading:19586936-Genetic Markers,
pubmed-meshheading:19586936-Humans,
pubmed-meshheading:19586936-Leukemia, T-Cell,
pubmed-meshheading:19586936-Loss of Heterozygosity,
pubmed-meshheading:19586936-Male,
pubmed-meshheading:19586936-Microsatellite Repeats,
pubmed-meshheading:19586936-Precursor T-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19586936-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19586936-Survival Rate,
pubmed-meshheading:19586936-Tumor Suppressor Protein p53,
pubmed-meshheading:19586936-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia.
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pubmed:affiliation |
Department of Pediatric Hematology and Oncology, Justus Liebig University, Giessen, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study
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