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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-9
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pubmed:abstractText |
Syntheses and in vitro antimalarial evaluation of 42 new thioureidoquinazolines have been carried out. Several analogs showed promising antimalarial effect in the in vitro investigation against chloroquine-sensitive 3D7 strain of Plasmodium falciparum whereas one of the compounds shows 50% curative effect in the mouse model at an oral dose of 100mg/kg x 4 days against multidrug resistant Plasmodium yoelii nigeriensis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1768-3254
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4404-12
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pubmed:meshHeading |
pubmed-meshheading:19586687-Animals,
pubmed-meshheading:19586687-Antimalarials,
pubmed-meshheading:19586687-Cell Survival,
pubmed-meshheading:19586687-Cercopithecus aethiops,
pubmed-meshheading:19586687-Female,
pubmed-meshheading:19586687-Malaria,
pubmed-meshheading:19586687-Male,
pubmed-meshheading:19586687-Mice,
pubmed-meshheading:19586687-Molecular Structure,
pubmed-meshheading:19586687-Parasitic Sensitivity Tests,
pubmed-meshheading:19586687-Plasmodium falciparum,
pubmed-meshheading:19586687-Plasmodium yoelii,
pubmed-meshheading:19586687-Quinazolines,
pubmed-meshheading:19586687-Structure-Activity Relationship,
pubmed-meshheading:19586687-Thiourea,
pubmed-meshheading:19586687-Vero Cells
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pubmed:year |
2009
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pubmed:articleTitle |
Search for new pharmacophores for antimalarial activity. Part III: synthesis and bioevaluation of new 6-thioureido-4-anilinoquinazolines.
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pubmed:affiliation |
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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