Source:http://linkedlifedata.com/resource/pubmed/id/19585572
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2009-9-28
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pubmed:abstractText |
Interleukin-6 (IL-6) may play a role in the pathogenesis of hepatocellular carcinoma (HCC). Recently, it was reported in mouse models that estrogen-mediated inhibition of IL-6 production explains the gender disparity in HCC. We conducted a retrospective cohort study to examine whether this hypothesis is applicable to human HCC. We enrolled 330 patients with chronic hepatitis C whose serum samples were collected between January 1994 and December 2002. Serum IL-6 concentrations were measured and patients were divided into three groups according to IL-6 levels: low, middle, and high. We evaluated the association between serum IL-6 levels and the risk of subsequent HCC development, including subgroup analysis on each gender. During the follow-up period (mean 9.0 yr), HCC developed in 126 patients. The incidence rates differed significantly among the three groups (p = 0.015), increasing in accordance with serum IL-6 levels. However, unexpectedly, this tendency was significant only in female patients. In a multivariate analysis, higher serum IL-6 level was an independent risk factor for HCC development in female patients, with a hazard ratio of 1.61. Although female patients showed a weak negative correlation between serum IL-6 levels and estradiol levels, the lower risk of HCC in female patients cannot be fully explained by estrogen-mediated inhibition of IL-6 production. In conclusion, higher serum IL-6 level was an independent risk factor for HCC development in female but not male chronic hepatitis C patients. Measurement of serum IL-6 levels may provide useful information for predicting future HCC development in female chronic hepatitis C patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-0215
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pubmed:author |
pubmed-author:HayakawaYokuY,
pubmed-author:KatoNaoyaN,
pubmed-author:KinoshitaHirotoH,
pubmed-author:MaedaShinS,
pubmed-author:MasuzakiRyotaR,
pubmed-author:NakagawaHayatoH,
pubmed-author:OhkiTakamasaT,
pubmed-author:OmataMasaoM,
pubmed-author:ShiinaShuichiroS,
pubmed-author:TateishiRyosukeR,
pubmed-author:YamakadoMinoruM,
pubmed-author:YoshidaHaruhikoH
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2264-9
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pubmed:meshHeading |
pubmed-meshheading:19585572-Carcinoma, Hepatocellular,
pubmed-meshheading:19585572-Cohort Studies,
pubmed-meshheading:19585572-Estrogens,
pubmed-meshheading:19585572-Female,
pubmed-meshheading:19585572-Hepacivirus,
pubmed-meshheading:19585572-Hepatitis C, Chronic,
pubmed-meshheading:19585572-Humans,
pubmed-meshheading:19585572-Interleukin-6,
pubmed-meshheading:19585572-Liver Neoplasms,
pubmed-meshheading:19585572-Male,
pubmed-meshheading:19585572-Middle Aged,
pubmed-meshheading:19585572-Prognosis,
pubmed-meshheading:19585572-Retrospective Studies,
pubmed-meshheading:19585572-Risk Factors,
pubmed-meshheading:19585572-Sex Factors,
pubmed-meshheading:19585572-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences.
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pubmed:affiliation |
Department of Gastroenterology, University of Tokyo, Tokyo 113-8655, Japan. n-hayato@yf7.so-net.ne.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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