| pubmed-article:19585511 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0287531 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C1705047 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C2697656 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0175697 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C1333257 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0024426 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19585511 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:19585511 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:19585511 | pubmed:dateCreated | 2009-7-14 | lld:pubmed |
| pubmed-article:19585511 | pubmed:abstractText | MAPK phosphatase-1 (MKP-1) is a protein phosphatase that plays a crucial role in innate immunity. This phosphatase inactivates ERK1/2, which are involved in two opposite functional activities of the macrophage, namely proliferation and activation. Here we found that although macrophage proliferation and activation induce MKP-1 with different kinetics, gene expression is mediated by the proximal promoter sequences localized between -380 and -180 bp. Mutagenesis experiments of the proximal element determined that CRE/AP-1 is required for LPS- or M-CSF-induced activation of the MKP-1 gene. Moreover, the results from gel shift analysis and chromatin immunoprecipitation indicated that c-Jun and CREB bind to the CRE/AP-1 box. The distinct kinetics shown by M-CSF and LPS correlates with the induction of JNK and c-jun, as well as the requirement for Raf-1. The signal transduction pathways that activate the induction of MKP-1 correlate kinetically with induction by M-CSF and LPS. | lld:pubmed |
| pubmed-article:19585511 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19585511 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19585511 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19585511 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19585511 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:LloberasJorge... | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:CeladaAntonio... | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:SerraMariaM | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:Sánchez-Tilló... | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:CaellesCarmeC | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:de la... | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:FarreraConsol... | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:AlvarezEvaE | lld:pubmed |
| pubmed-article:19585511 | pubmed:author | pubmed-author:Casals-CasasC... | lld:pubmed |
| pubmed-article:19585511 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19585511 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:19585511 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19585511 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19585511 | pubmed:pagination | 1902-13 | lld:pubmed |
| pubmed-article:19585511 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:meshHeading | pubmed-meshheading:19585511... | lld:pubmed |
| pubmed-article:19585511 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19585511 | pubmed:articleTitle | CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation. | lld:pubmed |
| pubmed-article:19585511 | pubmed:affiliation | Institute for Research in Biomedicine, University of Barcelona, Spain. | lld:pubmed |
| pubmed-article:19585511 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19585511 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:26419 | entrezgene:pubmed | pubmed-article:19585511 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19585511 | lld:pubmed |
