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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-12-24
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pubmed:abstractText |
To investigate the synergistic inhibitory effects of the combination of 5-fluorouracil (5-FU) with the natural flavanoid oroxylin A on human hepatocellular carcinoma cells HepG2 in vitro and on transplanted murine hepatoma 22 (H22) tumors in vivo and the preliminary mechanisms.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,7-dihydroxy-6-methoxy-2-phenylchro...,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydrouracil Dehydrogenase (NADP),
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidylate Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1432-0843
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
481-9
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pubmed:dateRevised |
2011-2-4
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pubmed:meshHeading |
pubmed-meshheading:19585117-Animals,
pubmed-meshheading:19585117-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19585117-Apoptosis,
pubmed-meshheading:19585117-Blotting, Western,
pubmed-meshheading:19585117-Carcinoma, Hepatocellular,
pubmed-meshheading:19585117-Caspase 3,
pubmed-meshheading:19585117-Cell Line, Tumor,
pubmed-meshheading:19585117-Cyclooxygenase 2,
pubmed-meshheading:19585117-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:19585117-Dose-Response Relationship, Drug,
pubmed-meshheading:19585117-Drug Synergism,
pubmed-meshheading:19585117-Flavonoids,
pubmed-meshheading:19585117-Fluorouracil,
pubmed-meshheading:19585117-Humans,
pubmed-meshheading:19585117-Liver Neoplasms, Experimental,
pubmed-meshheading:19585117-Male,
pubmed-meshheading:19585117-Mice,
pubmed-meshheading:19585117-Molecular Structure,
pubmed-meshheading:19585117-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:19585117-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:19585117-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19585117-Thymidylate Synthase,
pubmed-meshheading:19585117-Tumor Burden,
pubmed-meshheading:19585117-Tumor Suppressor Protein p53
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pubmed:year |
2010
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pubmed:articleTitle |
Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice.
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pubmed:affiliation |
Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, 210009, Nanjing, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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