| pubmed-article:1958441 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1958441 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1958441 | lifeskim:mentions | umls-concept:C0020365 | lld:lifeskim |
| pubmed-article:1958441 | lifeskim:mentions | umls-concept:C0017551 | lld:lifeskim |
| pubmed-article:1958441 | lifeskim:mentions | umls-concept:C0011082 | lld:lifeskim |
| pubmed-article:1958441 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:1958441 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1958441 | pubmed:dateCreated | 1992-1-8 | lld:pubmed |
| pubmed-article:1958441 | pubmed:abstractText | 1. N-acetylation and debrisoquine hydroxylation phenotypes were determined in 54 patients with Gilbert's syndrome and in 247 (sulphamethazine) and 76 (debrisoquine) non-related healthy volunteers. 2. Forty (74.1%) of the patients and 135 (54.7%) of the healthy volunteers were slow acetylators (chi 2 = 6.87). In the patients, the cumulative urinary excretion of sulphamethazine up to 6 h (Ae(0,6)) was significantly lower. No differences in the frequency of debrisoquine poor metabolizers were observed: Gilbert's syndrome 5/54 (9.3%), healthy volunteers 5/76 (6.6%). The metabolic ratios were similar in both groups as well as the urinary recoveries of debrisoquine and its 4-hydroxy metabolite. 3. Gilbert's syndrome seems to be related in some way to N-acetylation but not to the debrisoquine hydroxylation polymorphism. | lld:pubmed |
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| pubmed-article:1958441 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1958441 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1958441 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1958441 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1958441 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1958441 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1958441 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:SiegmundWW | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:FrankeGG | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:MeiselPP | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:FenglerJ DJD | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:ZschiescheMM | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:WulkowRR | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:EikeOO | lld:pubmed |
| pubmed-article:1958441 | pubmed:author | pubmed-author:EikeEE | lld:pubmed |
| pubmed-article:1958441 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1958441 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:1958441 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1958441 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1958441 | pubmed:pagination | 467-72 | lld:pubmed |
| pubmed-article:1958441 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
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| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
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| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
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| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:meshHeading | pubmed-meshheading:1958441-... | lld:pubmed |
| pubmed-article:1958441 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1958441 | pubmed:articleTitle | N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome. | lld:pubmed |
| pubmed-article:1958441 | pubmed:affiliation | Department of Clinical Pharmacology, University of Greifswald, Germany. | lld:pubmed |
| pubmed-article:1958441 | pubmed:publicationType | Journal Article | lld:pubmed |
