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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-1-8
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pubmed:abstractText |
1. N-acetylation and debrisoquine hydroxylation phenotypes were determined in 54 patients with Gilbert's syndrome and in 247 (sulphamethazine) and 76 (debrisoquine) non-related healthy volunteers. 2. Forty (74.1%) of the patients and 135 (54.7%) of the healthy volunteers were slow acetylators (chi 2 = 6.87). In the patients, the cumulative urinary excretion of sulphamethazine up to 6 h (Ae(0,6)) was significantly lower. No differences in the frequency of debrisoquine poor metabolizers were observed: Gilbert's syndrome 5/54 (9.3%), healthy volunteers 5/76 (6.6%). The metabolic ratios were similar in both groups as well as the urinary recoveries of debrisoquine and its 4-hydroxy metabolite. 3. Gilbert's syndrome seems to be related in some way to N-acetylation but not to the debrisoquine hydroxylation polymorphism.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-100326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-13618635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-13632313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-13666960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-13946194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-14013759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-14192572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-14220904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2100800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2564084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2616620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2664821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2731181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2736200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-2846954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-3113968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-3652049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-3943223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-4897277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-5071284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-533695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-5455561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-5770050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-6054997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-6410201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-6504125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-6510457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-6807787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-7134940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-7286909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-7378044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1958441-814028
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1958441-Acetylation,
pubmed-meshheading:1958441-Adolescent,
pubmed-meshheading:1958441-Adult,
pubmed-meshheading:1958441-Aged,
pubmed-meshheading:1958441-Debrisoquin,
pubmed-meshheading:1958441-Female,
pubmed-meshheading:1958441-Gilbert Disease,
pubmed-meshheading:1958441-Humans,
pubmed-meshheading:1958441-Hydroxylation,
pubmed-meshheading:1958441-Male,
pubmed-meshheading:1958441-Middle Aged,
pubmed-meshheading:1958441-Phenotype,
pubmed-meshheading:1958441-Polymorphism, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
N-acetylation and debrisoquine hydroxylation polymorphisms in patients with Gilbert's syndrome.
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pubmed:affiliation |
Department of Clinical Pharmacology, University of Greifswald, Germany.
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pubmed:publicationType |
Journal Article
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