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pubmed-article:19584164pubmed:abstractTextHepatoblastoma represents the most frequent malignant liver tumor in childhood. The phosphatidylinositol-3'-kinase (PI3K)/AKT pathway is crucial in downstream signaling of multiple receptor tyrosine kinases of pathogenic importance in hepatoblastoma. Increased PI3K/AKT signaling pathway activity and activating mutations of PIK3CA, encoding a PI3K catalytic subunit, have been reported in different childhood tumors. The current study was done to analyze the role of PI3K/AKT signaling in hepatoblastoma.lld:pubmed
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pubmed-article:19584164pubmed:affiliationDepartment of Pathology and Neuropathology, University of Bonn Medical Center, Sigmund-Freud-St. 25, Bonn D-53105, Germany. wolfgang.hartmann@uni-bonn.delld:pubmed
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