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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
Hepatoblastoma represents the most frequent malignant liver tumor in childhood. The phosphatidylinositol-3'-kinase (PI3K)/AKT pathway is crucial in downstream signaling of multiple receptor tyrosine kinases of pathogenic importance in hepatoblastoma. Increased PI3K/AKT signaling pathway activity and activating mutations of PIK3CA, encoding a PI3K catalytic subunit, have been reported in different childhood tumors. The current study was done to analyze the role of PI3K/AKT signaling in hepatoblastoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(4-morpholinyl)-8-phenyl-4H-1-benz...,
http://linkedlifedata.com/resource/pubmed/chemical/Chromones,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PI3KCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BuettnerReinhardR,
pubmed-author:CzerwitzkiJacquelineJ,
pubmed-author:EndlElmarE,
pubmed-author:FriedrichsNicolausN,
pubmed-author:HartmannWolfgangW,
pubmed-author:KüchlerJanJ,
pubmed-author:KochArendA,
pubmed-author:LeuschnerIvoI,
pubmed-author:MetzgerDagmarD,
pubmed-author:PietschTorstenT,
pubmed-author:SteinerSusanneS,
pubmed-author:WahaAnkeA,
pubmed-author:WurstPeterP,
pubmed-author:von SchweinitzDietrichD
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4538-45
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:19584164-Adolescent,
pubmed-meshheading:19584164-Adult,
pubmed-meshheading:19584164-Apoptosis,
pubmed-meshheading:19584164-Cell Line, Tumor,
pubmed-meshheading:19584164-Cell Survival,
pubmed-meshheading:19584164-Child,
pubmed-meshheading:19584164-Child, Preschool,
pubmed-meshheading:19584164-Chromones,
pubmed-meshheading:19584164-Cisplatin,
pubmed-meshheading:19584164-Drug Synergism,
pubmed-meshheading:19584164-Flow Cytometry,
pubmed-meshheading:19584164-Glycogen Synthase Kinase 3,
pubmed-meshheading:19584164-Hepatoblastoma,
pubmed-meshheading:19584164-Humans,
pubmed-meshheading:19584164-Immunohistochemistry,
pubmed-meshheading:19584164-Middle Aged,
pubmed-meshheading:19584164-Morpholines,
pubmed-meshheading:19584164-Mutation,
pubmed-meshheading:19584164-Nuclear Proteins,
pubmed-meshheading:19584164-Phosphorylation,
pubmed-meshheading:19584164-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:19584164-Protein Kinases,
pubmed-meshheading:19584164-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19584164-RNA Interference,
pubmed-meshheading:19584164-Signal Transduction,
pubmed-meshheading:19584164-TOR Serine-Threonine Kinases,
pubmed-meshheading:19584164-Transcription Factors,
pubmed-meshheading:19584164-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
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pubmed:affiliation |
Department of Pathology and Neuropathology, University of Bonn Medical Center, Sigmund-Freud-St. 25, Bonn D-53105, Germany. wolfgang.hartmann@uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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