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rdf:type |
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lifeskim:mentions |
umls-concept:C0023473,
umls-concept:C0087111,
umls-concept:C0205210,
umls-concept:C0439064,
umls-concept:C0449445,
umls-concept:C0681842,
umls-concept:C0683598,
umls-concept:C0871261,
umls-concept:C0935989,
umls-concept:C1332838,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2347946,
umls-concept:C2911692
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pubmed:issue |
14
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pubmed:dateCreated |
2009-7-16
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|
pubmed:abstractText |
Imatinib resistance is major cause of imatinib mesylate (IM) treatment failure in chronic myeloid leukemia (CML) patients. Several cellular and genetic mechanisms of imatinib resistance have been proposed, including amplification and overexpression of the BCR/ABL gene, the tyrosine kinase domain point mutations, and MDR1 gene overexpression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ABCG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A,
http://linkedlifedata.com/resource/pubmed/chemical/Fusion Proteins, bcr-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/POU2F1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/imatinib
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1078-0432
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4750-8
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pubmed:meshHeading |
pubmed-meshheading:19584153-ATP-Binding Cassette Transporters,
pubmed-meshheading:19584153-Adolescent,
pubmed-meshheading:19584153-Adult,
pubmed-meshheading:19584153-Aged,
pubmed-meshheading:19584153-Antineoplastic Agents,
pubmed-meshheading:19584153-Cytochrome P-450 CYP3A,
pubmed-meshheading:19584153-Drug Resistance, Neoplasm,
pubmed-meshheading:19584153-Female,
pubmed-meshheading:19584153-Fusion Proteins, bcr-abl,
pubmed-meshheading:19584153-Gene Frequency,
pubmed-meshheading:19584153-Genetic Predisposition to Disease,
pubmed-meshheading:19584153-Genotype,
pubmed-meshheading:19584153-Glycoproteins,
pubmed-meshheading:19584153-Humans,
pubmed-meshheading:19584153-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:19584153-Male,
pubmed-meshheading:19584153-Middle Aged,
pubmed-meshheading:19584153-Neoplasm Proteins,
pubmed-meshheading:19584153-Octamer Transcription Factor-1,
pubmed-meshheading:19584153-P-Glycoprotein,
pubmed-meshheading:19584153-Pharmacogenetics,
pubmed-meshheading:19584153-Piperazines,
pubmed-meshheading:19584153-Polymorphism, Single Nucleotide,
pubmed-meshheading:19584153-Prognosis,
pubmed-meshheading:19584153-Pyrimidines,
pubmed-meshheading:19584153-Treatment Outcome,
pubmed-meshheading:19584153-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.
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pubmed:affiliation |
Chronic Myelogenous Leukemia Group, Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea. drkiim@medimail.co.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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