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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-21
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pubmed:abstractText |
Doublecortin (DCX) is a microtubule-associated protein with regulatory roles in radial and tangential migration of neurons during cortical development. In normal adult cortex there is restricted expression, and DCX is widely used as a marker of neurogenesis. Imperfect corticogenesis is thought to underpin many focal cortical pathologies in epilepsy surgical series, including focal cortical dysplasia (FCD). The aim was to study DCX expression patterns in such lesions compared to normal developing and mature cortex.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1528-1167
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2619-28
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pubmed:meshHeading |
pubmed-meshheading:19583780-Adolescent,
pubmed-meshheading:19583780-Adult,
pubmed-meshheading:19583780-Animals,
pubmed-meshheading:19583780-Autopsy,
pubmed-meshheading:19583780-Blotting, Western,
pubmed-meshheading:19583780-Cell Migration Assays,
pubmed-meshheading:19583780-Child,
pubmed-meshheading:19583780-Child, Preschool,
pubmed-meshheading:19583780-Epilepsy,
pubmed-meshheading:19583780-Female,
pubmed-meshheading:19583780-Fluorescent Antibody Technique,
pubmed-meshheading:19583780-Gene Expression Regulation, Developmental,
pubmed-meshheading:19583780-Giant Cells,
pubmed-meshheading:19583780-Humans,
pubmed-meshheading:19583780-Immunohistochemistry,
pubmed-meshheading:19583780-Infant,
pubmed-meshheading:19583780-Male,
pubmed-meshheading:19583780-Malformations of Cortical Development,
pubmed-meshheading:19583780-Microtubule-Associated Proteins,
pubmed-meshheading:19583780-Neocortex,
pubmed-meshheading:19583780-Neurogenesis,
pubmed-meshheading:19583780-Neurons,
pubmed-meshheading:19583780-Neuropeptides,
pubmed-meshheading:19583780-Tuberous Sclerosis
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pubmed:year |
2009
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pubmed:articleTitle |
Doublecortin expression in focal cortical dysplasia in epilepsy.
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pubmed:affiliation |
Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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