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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0038952,
umls-concept:C0079419,
umls-concept:C0441785,
umls-concept:C0521447,
umls-concept:C0521451,
umls-concept:C0681842,
umls-concept:C0919532,
umls-concept:C0920269,
umls-concept:C1442161,
umls-concept:C1446468,
umls-concept:C1527249,
umls-concept:C1704807,
umls-concept:C1707520
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-25
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pubmed:abstractText |
Malfunction of mismatch repair (MMR) system and p53 produces nuclear genomic instability and is involved in colorectal tumorigenesis. In addition to a nuclear genome, eukaryotic cells have cytoplasmic genomes that are compartmentalized in the mitochondria. The aims of this study were to detect the mitochondrial genomic instability (mtGI) in colorectal carcinomas, and to explore its relationship with nuclear genetic alterations and its prognostic meaning.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Mitochondrial,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1534-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2918-25
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pubmed:meshHeading |
pubmed-meshheading:19582509-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19582509-Adult,
pubmed-meshheading:19582509-Aged,
pubmed-meshheading:19582509-Aged, 80 and over,
pubmed-meshheading:19582509-Cell Nucleus,
pubmed-meshheading:19582509-Colorectal Neoplasms,
pubmed-meshheading:19582509-DNA, Mitochondrial,
pubmed-meshheading:19582509-Female,
pubmed-meshheading:19582509-Follow-Up Studies,
pubmed-meshheading:19582509-Humans,
pubmed-meshheading:19582509-Loss of Heterozygosity,
pubmed-meshheading:19582509-Male,
pubmed-meshheading:19582509-Microsatellite Instability,
pubmed-meshheading:19582509-Middle Aged,
pubmed-meshheading:19582509-Mitochondria,
pubmed-meshheading:19582509-MutS Homolog 2 Protein,
pubmed-meshheading:19582509-Neoplasm Staging,
pubmed-meshheading:19582509-Nuclear Proteins,
pubmed-meshheading:19582509-Prognosis,
pubmed-meshheading:19582509-Sequence Deletion,
pubmed-meshheading:19582509-Survival Rate,
pubmed-meshheading:19582509-Tumor Markers, Biological,
pubmed-meshheading:19582509-Tumor Suppressor Protein p53
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pubmed:year |
2009
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pubmed:articleTitle |
Mitochondrial genomic instability in colorectal cancer: no correlation to nuclear microsatellite instability and allelic deletion of hMSH2, hMLH1, and p53 genes, but prediction of better survival for Dukes' stage C disease.
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pubmed:affiliation |
School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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