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pubmed-article:19581416pubmed:abstractTextAtherosclerosis is accelerated in subjects with type 2 diabetes by unknown mechanisms. We identified tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of A disintegrin and metalloprotease domain 17 (ADAM17) and other matrix metalloproteinases (MMPs), as a gene modifier for insulin resistance and vascular inflammation in mice. We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression.lld:pubmed
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pubmed-article:19581416pubmed:articleTitleTIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.lld:pubmed
pubmed-article:19581416pubmed:affiliationDepartment of Internal Medicine, University of Rome Tor Vergata, Rome, Italy.lld:pubmed
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