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rdf:type |
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lifeskim:mentions |
umls-concept:C0011860,
umls-concept:C0205217,
umls-concept:C0332307,
umls-concept:C0392756,
umls-concept:C0681850,
umls-concept:C1336630,
umls-concept:C1423062,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811,
umls-concept:C2936350
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pubmed:issue |
10
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pubmed:dateCreated |
2009-10-1
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pubmed:abstractText |
Atherosclerosis is accelerated in subjects with type 2 diabetes by unknown mechanisms. We identified tissue inhibitor of metalloproteinase 3 (TIMP3), the endogenous inhibitor of A disintegrin and metalloprotease domain 17 (ADAM17) and other matrix metalloproteinases (MMPs), as a gene modifier for insulin resistance and vascular inflammation in mice. We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:CardelliniMarinaM,
pubmed-author:CasagrandeVivianaV,
pubmed-author:FedericiMassimoM,
pubmed-author:FolliFrancoF,
pubmed-author:IppolitiArnaldoA,
pubmed-author:LauroRenatoR,
pubmed-author:MarinoAriannaA,
pubmed-author:MartelliEugenioE,
pubmed-author:MaurielloAlessandroA,
pubmed-author:MenghiniRossellaR,
pubmed-author:PorzioOttaviaO,
pubmed-author:RizzaStefanoS,
pubmed-author:SoliniAnnaA
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pubmed:issnType |
Electronic
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2396-401
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pubmed:dateRevised |
2010-10-4
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pubmed:meshHeading |
pubmed-meshheading:19581416-ADAM Proteins,
pubmed-meshheading:19581416-Animals,
pubmed-meshheading:19581416-Atherosclerosis,
pubmed-meshheading:19581416-Carotid Arteries,
pubmed-meshheading:19581416-Carotid Artery Diseases,
pubmed-meshheading:19581416-Diabetes Mellitus, Type 2,
pubmed-meshheading:19581416-Humans,
pubmed-meshheading:19581416-Matrix Metalloproteinase 9,
pubmed-meshheading:19581416-Mice,
pubmed-meshheading:19581416-Reference Values,
pubmed-meshheading:19581416-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19581416-Sirtuin 1,
pubmed-meshheading:19581416-Sirtuins,
pubmed-meshheading:19581416-Tissue Inhibitor of Metalloproteinase-3
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pubmed:year |
2009
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pubmed:articleTitle |
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
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pubmed:affiliation |
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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