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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-12
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pubmed:abstractText |
Cytomegalovirus (CMV) infection is the most frequent infectious disease following organ transplantation. Strategies to prevent this infection remain a matter for debate, and discovering genetic risk factors might assist in adapting preventive strategies. By inhibiting IFNgamma production, programmed death 1 (PD-1) has a crucial role in anti-CMV immune response. A single nucleotide polymorphism (SNP) within intron 4 of the gene (rs11568821), called PD-1.3, has recently been reported to be clinically relevant in several immune disorders. However, its association with CMV infection has never been reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1468-6244
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19581275-Antigens, CD,
pubmed-meshheading:19581275-Apoptosis Regulatory Proteins,
pubmed-meshheading:19581275-Cytomegalovirus Infections,
pubmed-meshheading:19581275-Genetic Association Studies,
pubmed-meshheading:19581275-Genetic Predisposition to Disease,
pubmed-meshheading:19581275-Humans,
pubmed-meshheading:19581275-Kidney Transplantation,
pubmed-meshheading:19581275-Polymorphism, Single Nucleotide,
pubmed-meshheading:19581275-Postoperative Complications,
pubmed-meshheading:19581275-Programmed Cell Death 1 Receptor
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pubmed:year |
2010
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pubmed:articleTitle |
Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation.
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pubmed:affiliation |
Université François Rabelais de Tours, EA 4245 Cellules Dendritiques Immunomodulation et Greffes, UFR de Médecine, Tours, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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