| pubmed-article:19580490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C0430054 | lld:lifeskim |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C0751973 | lld:lifeskim |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C1705053 | lld:lifeskim |
| pubmed-article:19580490 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:19580490 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19580490 | pubmed:dateCreated | 2009-7-7 | lld:pubmed |
| pubmed-article:19580490 | pubmed:abstractText | In an effort to identify proteomic changes that may be useful for radiation biodosimetry, human cells of hematological origin were treated with ionizing radiation or mock-irradiated and then harvested at different times after treatment. Protein lysates were generated from these cells and evaluated by Western blotting using a panel of 301 commercially available antibodies targeting 161 unique proteins. From this screen, we identified 55 ionizing radiation-responsive proteins, including 14 proteins not previously reported to be radiation-responsive at the protein level. The data from this large-scale screen have been assembled into a public website ( http://labs.fhcrc.org/paulovich/biodose_index.html ) that may be of value to the radiation community both as a source of putative biomarkers for biodosimetry and also as a source of validation data on commercially available antibodies that detect radiation-responsive proteins. Using a panel of candidate radiation biomarkers in human cell lines, we demonstrate the feasibility of assembling a complementary panel of radiation-responsive proteins. Furthermore, we demonstrate the feasibility of using blood cell-based proteomic changes for biodosimetry by demonstrating detection of protein changes in circulating cells after total-body irradiation in a canine model. | lld:pubmed |
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| pubmed-article:19580490 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19580490 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580490 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19580490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19580490 | pubmed:month | May | lld:pubmed |
| pubmed-article:19580490 | pubmed:issn | 0033-7587 | lld:pubmed |
| pubmed-article:19580490 | pubmed:author | pubmed-author:IveyRichard... | lld:pubmed |
| pubmed-article:19580490 | pubmed:author | pubmed-author:LorentzenTrav... | lld:pubmed |
| pubmed-article:19580490 | pubmed:author | pubmed-author:PaulovichAman... | lld:pubmed |
| pubmed-article:19580490 | pubmed:author | pubmed-author:SubramanianOb... | lld:pubmed |
| pubmed-article:19580490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19580490 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:19580490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19580490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19580490 | pubmed:pagination | 549-61 | lld:pubmed |
| pubmed-article:19580490 | pubmed:dateRevised | 2011-6-6 | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:meshHeading | pubmed-meshheading:19580490... | lld:pubmed |
| pubmed-article:19580490 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19580490 | pubmed:articleTitle | Antibody-based screen for ionizing radiation-dependent changes in the Mammalian proteome for use in biodosimetry. | lld:pubmed |
| pubmed-article:19580490 | pubmed:affiliation | Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. | lld:pubmed |
| pubmed-article:19580490 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19580490 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
