Linked Life Data

19579252

Source:http://linkedlifedata.com/resource/pubmed/id/19579252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-8-31
pubmed:abstractText
A dimeric calixarene, with an aliphatic C(6)-bridge and six anilinium head groups at its upper rim, preferably complexes diphosphates and oligonucleotides with more than 10 bonds between both anionic moieties. Free binding energies correlate with the length of the aliphatic bridge in a roughly linear fashion. The binding event, which is monitored by fluorescence titrations and competition experiments, relies on Coulomb interactions, as opposed to a nonpolar variant with tert-butyl instead of ammonium groups; here, hydrophobic forces prevail, rendering the calixarene dimer selective for less polar cofactors such as FAD. The best guest for the hexaanilinium dimer is found in ssDNA, which carries multiple copies of the optimal trinucleotide for maximum attraction towards the extended cationic host. The recognition event is also observed in the environment of a lipid monolayer, and provides a means to quantify dimer diphosphate interactions by measuring p/A shifts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1861-471X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1458-64
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Calixarene dimers as host molecules for biologically important di- and oligophosphates.
pubmed:affiliation
Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran. zadmard@ccerci.ac.ir
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't