Source:http://linkedlifedata.com/resource/pubmed/id/19578107
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2009-7-6
|
| pubmed:abstractText |
The aims of this study were to examine the predictors of time to neuropsychiatric (NP) damage and its impact on mortality in 632 systemic lupus erythematosus African-American, Hispanic and Caucasian LUpus in MInorities: NAture versus Nurture (LUMINA) patients, age >or= 16 years and disease duration <or=5 years at baseline (T0). Time-to-NP damage and its impact on mortality were examined by Cox proportional hazards regressions. A total of 185 (29.3%) patients developed NP damage over a mean (SD) disease duration of 5.6 (3.7) years. After adjusting for NP manifestations present, older age [Hazard ratio (HR) = 1.02; 95% Confidence interval (CI) 1.00-1.04], Caucasian ethnicity (HR = 1.87; 95% CI, 1.22-2.87), disease activity over the disease course (HR = 1.16; 95% CI, 1.12-1.21), diabetes (HR = 3.47; 95% CI, 1.44-8.38) and abnormal illness-related behaviours (HR = 1.05; 95% CI, 1.02-1.08) were associated with a shorter time-to-NP damage. Photosensitivity (HR = 0.65; 95% CI, 0.44-0.95), anaemia (HR = 0.56; 95% CI, 0.31-0.98), Raynaud's phenomenon (HR = 0.49; 95% CI, 0.34-0.72), a medium dose of prednisone (HR = 0.56; 95% CI, 0.35-0.92) and hydroxychloroquine use (HR = 0.58; 95% CI, 0.36-0.93) were associated with a longer time. NP damage did not contribute to mortality. Older age, Caucasian ethnicity, disease activity and abnormal illness-related behaviours are associated with a shorter time-to-NP damage; hydroxychloroquine and a medium dose of prednisone with a longer time.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0961-2033
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
822-30
|
| pubmed:meshHeading |
pubmed-meshheading:19578107-Adult,
pubmed-meshheading:19578107-African Americans,
pubmed-meshheading:19578107-Age Factors,
pubmed-meshheading:19578107-Cohort Studies,
pubmed-meshheading:19578107-Disease Progression,
pubmed-meshheading:19578107-European Continental Ancestry Group,
pubmed-meshheading:19578107-Female,
pubmed-meshheading:19578107-Hispanic Americans,
pubmed-meshheading:19578107-Humans,
pubmed-meshheading:19578107-Illness Behavior,
pubmed-meshheading:19578107-Incidence,
pubmed-meshheading:19578107-Longitudinal Studies,
pubmed-meshheading:19578107-Lupus Erythematosus, Systemic,
pubmed-meshheading:19578107-Lupus Vasculitis, Central Nervous System,
pubmed-meshheading:19578107-Male,
pubmed-meshheading:19578107-Middle Aged,
pubmed-meshheading:19578107-Multivariate Analysis,
pubmed-meshheading:19578107-Proportional Hazards Models,
pubmed-meshheading:19578107-Severity of Illness Index,
pubmed-meshheading:19578107-Time Factors
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Time to neuropsychiatric damage occurrence in LUMINA (LXVI): a multi-ethnic lupus cohort.
|
| pubmed:affiliation |
Department of Medicine (Division of Clinical Immunology and Rheumatology), School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|