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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-6
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pubmed:abstractText |
The inflammatory process of aortic stenosis involves the differentiation of aortic valve myofibroblasts into osteoblasts. Osteopontin, a proinflammatory glycoprotein, both stimulates differentiation of myofibroblasts and regulates the deposition of calcium by osteoblasts. Osteopontin levels are increased in patients with such conditions as end-stage renal disease, ectopic calcification, and autoimmune disease. We hypothesized that increased plasma osteopontin levels might be associated with the presence of aortic valve calcification and stenosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-685X
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pubmed:author |
pubmed-author:Diaz-CartelleJuanJ,
pubmed-author:FerrariGiovanniG,
pubmed-author:GallowayAubrey CAC,
pubmed-author:GrauJuan BJB,
pubmed-author:GrossiEugene AEA,
pubmed-author:HeretisKatherineK,
pubmed-author:KronzonItzhakI,
pubmed-author:MignattiPaoloP,
pubmed-author:PassHarvey IHI,
pubmed-author:PerkGilaG,
pubmed-author:PintucciGiuseppeG,
pubmed-author:RosenzweigBarryB,
pubmed-author:SkolnickAdamA,
pubmed-author:YuPey-JenPJ
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-9
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pubmed:dateRevised |
2011-5-5
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Correlation between plasma osteopontin levels and aortic valve calcification: potential insights into the pathogenesis of aortic valve calcification and stenosis.
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pubmed:affiliation |
Department of Cardiothoracic Surgery, New York University Medical Center, New York, NY 10016, USA.
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pubmed:publicationType |
Journal Article
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