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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-7-6
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pubmed:abstractText |
Vascular endothelial growth factor, a critical factor in angiogenesis, mediates stem cell paracrine protective effects on ischemic myocardium. Studies on the role of sex in stem cell function have demonstrated that female mesenchymal stem cells produce greater vascular endothelial growth factor and provide better cardiac protection compared with male mesenchymal stem cells. The purpose of this study was to determine the mechanisms by which estrogen affects mesenchymal stem cell function as a potential therapeutic measure during ex vivo expansion, before therapeutic use.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Propionates,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/diarylpropionitrile,
http://linkedlifedata.com/resource/pubmed/chemical/propyl pyrazole triol
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-71, 171.e1
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:19577074-Animals,
pubmed-meshheading:19577074-Cells, Cultured,
pubmed-meshheading:19577074-Dose-Response Relationship, Drug,
pubmed-meshheading:19577074-Estradiol,
pubmed-meshheading:19577074-Estrogen Receptor alpha,
pubmed-meshheading:19577074-Estrogen Receptor beta,
pubmed-meshheading:19577074-Female,
pubmed-meshheading:19577074-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19577074-MAP Kinase Signaling System,
pubmed-meshheading:19577074-Male,
pubmed-meshheading:19577074-Mesenchymal Stem Cells,
pubmed-meshheading:19577074-Mice,
pubmed-meshheading:19577074-Mice, Inbred C57BL,
pubmed-meshheading:19577074-Mice, Knockout,
pubmed-meshheading:19577074-Mitogen-Activated Protein Kinases,
pubmed-meshheading:19577074-Nitriles,
pubmed-meshheading:19577074-Propionates,
pubmed-meshheading:19577074-Pyrazoles,
pubmed-meshheading:19577074-STAT3 Transcription Factor,
pubmed-meshheading:19577074-Sex Characteristics,
pubmed-meshheading:19577074-Transcriptional Activation,
pubmed-meshheading:19577074-Vascular Endothelial Growth Factor A
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pubmed:year |
2009
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pubmed:articleTitle |
Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1alpha mediates estrogen receptor-alpha-induced mesenchymal stem cell vascular endothelial growth factor production.
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pubmed:affiliation |
Department of Surgery, Indiana University School of Medicine, Indianapolis, Ind, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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