| pubmed-article:19576865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1420644 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1705000 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1516170 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19576865 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19576865 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19576865 | pubmed:dateCreated | 2009-10-5 | lld:pubmed |
| pubmed-article:19576865 | pubmed:abstractText | There is current evidence implicating the Wnt/beta-catenin/TCF pathway in breast cancer. We investigated the effect of para- and meta-positional isomers of nitric oxide-releasing aspirin (NO-ASA), and aspirin (ASA) on MCF-7 human breast cancer cell growth and beta-catenin/TCF signaling. The p- and m-NO-ASA isomers strongly inhibited cell growth and beta-catenin/TCF transcriptional activity compared to ASA; the IC50s for growth inhibition were 57+/-4, 193+/-10 and >5000microM, and for transcriptional inhibition they were 12+/-1.8, 75+/-6.5 and >5000microM for p-, m-NO-ASA and ASA, respectively. p-NO-ASA reduced the expression of Wnt/beta-catenin downstream target gene cyclin D1, and total cellular beta-catenin levels. COX-2 expression was induced by p-NO-ASA, protein kinase C inhibitors reversed this induction. p-NO-ASA blocked the cell cycle transition at S to G2/M phase. These studies suggest a targeted chemopreventive/chemotherapeutic potential for NO-ASA against breast cancer. | lld:pubmed |
| pubmed-article:19576865 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19576865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19576865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19576865 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19576865 | pubmed:issn | 1873-2968 | lld:pubmed |
| pubmed-article:19576865 | pubmed:author | pubmed-author:NathNiharikaN | lld:pubmed |
| pubmed-article:19576865 | pubmed:author | pubmed-author:KashfiKhosrow... | lld:pubmed |
| pubmed-article:19576865 | pubmed:author | pubmed-author:VassellRashid... | lld:pubmed |
| pubmed-article:19576865 | pubmed:author | pubmed-author:Chattopadhyay... | lld:pubmed |
| pubmed-article:19576865 | pubmed:author | pubmed-author:KoganMarselM | lld:pubmed |
| pubmed-article:19576865 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19576865 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19576865 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:19576865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19576865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19576865 | pubmed:pagination | 1298-304 | lld:pubmed |
| pubmed-article:19576865 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:meshHeading | pubmed-meshheading:19576865... | lld:pubmed |
| pubmed-article:19576865 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19576865 | pubmed:articleTitle | Nitro-aspirin inhibits MCF-7 breast cancer cell growth: effects on COX-2 expression and Wnt/beta-catenin/TCF-4 signaling. | lld:pubmed |
| pubmed-article:19576865 | pubmed:affiliation | Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, United States. nnath@nyit.edu | lld:pubmed |
| pubmed-article:19576865 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19576865 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19576865 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
