Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-7-16
pubmed:abstractText
The recognition of viral components by host pattern-recognition receptors triggers the induction of the antiviral innate immune response. Toll-like receptor 9 (TLR9) and NLRP3 inflammasome were shown to be the principal specific sensors of viral double-stranded DNA. Here we present evidence that macrophages in vivo activated an innate immune response to a double-stranded DNA virus, adenovirus (Ad), independently of TLR9 or NLRP3 inflammasome. In response to Ad, macrophage-derived IL-1 alpha triggered IL-1RI-dependent production of a defined set of proinflammatory cytokines and chemokines. The IL-1 alpha-mediated response required a selective interaction of virus arginine-glycine-aspartic acid (RGD) motifs with macrophage beta(3) integrins. Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-10421844, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-10435584, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-10852125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-11130078, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-11739709, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-11799150, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-12742380, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-12855817, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-1384041, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-14567964, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-14965376, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-14983027, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-15190255, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-15681401, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-16129706, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-16407888, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-16407890, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-16544976, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-16943295, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-17038589, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-17038590, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-17229689, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-17251283, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-17934446, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-18288107, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-18549796, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-19116267, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-19120477, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-19604487, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-2115174, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-7535475, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8221887, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8477447, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8617221, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8630372, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8666901, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-8989993, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-9343240, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576795-9565638
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1097-4180
pubmed:author
pubmed:issnType
Electronic
pubmed:day
17
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
110-21
pubmed:dateRevised
2011-4-27
pubmed:meshHeading
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