Linked Life Data

19576361

Source:http://linkedlifedata.com/resource/pubmed/id/19576361

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-7-6
pubmed:abstractText
In 40% of children with symptomatic idiopathic dilated cardiomyopathy (IDC), medical therapy fails within 2 years of diagnosis. Strong evidence-based therapies are not available for these children, and how evidence-based therapies for adults with IDC should be applied to children is unclear. Using data from the National Heart, Lung, and Blood Institute's Pediatric Cardiomyopathy Registry, we compared practice patterns of initial therapies for children with IDC diagnosed from 1990 to 1995 (n = 350) and from 2000 to 2006 (n = 219). At diagnosis, 73% had symptomatic heart failure (HF), and 7% had > or =1 family member with IDC. Anti-HF medications were most commonly prescribed initially. Anti-HF medication use was similar across the 2 periods (84% and 87%, respectively), as was angiotensin-converting enzyme inhibitor use (66% and 70%, respectively). These medications were used more commonly in children with greater left ventricular dilation and poorer left ventricular fractional shortening and functional class (p <0.001). Beta-blocker use was 4% to 18% over the 2 periods. Treatments for pediatric IDC have changed little over the previous 25 years. Anti-HF medications remain the most common treatment, and they are often given to children with asymptomatic left ventricular dysfunction. Children with asymptomatic left ventricular dysfunction are often not offered angiotensin-converting enzyme inhibitors without echocardiographic evidence of advanced disease. In conclusion, therapeutic clinical trials are strongly indicated because practice variation is substantial and medical outcomes in these children have not improved in the previous several decades.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-10650321, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-12409541, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-1538019, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-15557009, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-15607659, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-1614922, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-16160202, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-17015543, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-17047217, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-17848651, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-18294492, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-1858677, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-2017982, http://linkedlifedata.com/resource/pubmed/commentcorrection/19576361-650346
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1879-1913
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-6
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Treating children with idiopathic dilated cardiomyopathy (from the Pediatric Cardiomyopathy Registry).
pubmed:affiliation
Department of Pediatrics, University of Miami, Leonard M. Miller School of Medicine, Miami, Florida, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural