Source:http://linkedlifedata.com/resource/pubmed/id/19575222
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-7-3
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| pubmed:abstractText |
A controlled, blinded and randomised multicentre field study evaluated the efficacy and safety of a new anthelmintic tablet formulation containing emodepside plus praziquantel (Profender tablets for dogs) in the treatment of gastrointestinal nematode and cestode infections in dogs in France, Germany, Portugal and Slovakia. Dogs positive for nematodes and/or cestodes (demonstrated by faecal egg counts and/or the presence of proglottids) were treated with emodepside plus praziquantel tablets (n = 239) or the reference product containing milbemycin oxime and praziquantel (Milbemax [n = 115]) at the recommended dose rate. Two faecal samples collected between 7 and 13 days after treatment were evaluated for proglottids, nematode and cestode eggs. No suspected adverse drug reactions were observed in the study. The following parasite species were identified: Trichuris vulpis, Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Dipylidium caninum, Taeniidae and Mesocestoides spp. Geometric mean nematode egg counts in dogs treated with emodepside plus praziquantel tablets were reduced by 99.9 % compared with a reduction of 99.6 % for the reference product. Statistical analysis demonstrated noninferiority of investigational versus reference product (p = 0.0342). None of the dogs treated with emodepside plus praziquantel or reference product remained positive for cestodes after treatment. The study demonstrated that emodepside plus praziquantel tablets are safe and highly efficacious against a broad spectrum of nematodes and cestodes under field conditions.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anthelmintics,
http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/Praziquantel,
http://linkedlifedata.com/resource/pubmed/chemical/Tablets,
http://linkedlifedata.com/resource/pubmed/chemical/emodepside,
http://linkedlifedata.com/resource/pubmed/chemical/milbemycin oxime
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1432-1955
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
105 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S23-9
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| pubmed:meshHeading |
pubmed-meshheading:19575222-Administration, Oral,
pubmed-meshheading:19575222-Animals,
pubmed-meshheading:19575222-Anthelmintics,
pubmed-meshheading:19575222-Cestoda,
pubmed-meshheading:19575222-Cestode Infections,
pubmed-meshheading:19575222-Depsipeptides,
pubmed-meshheading:19575222-Dog Diseases,
pubmed-meshheading:19575222-Dogs,
pubmed-meshheading:19575222-Double-Blind Method,
pubmed-meshheading:19575222-Feces,
pubmed-meshheading:19575222-France,
pubmed-meshheading:19575222-Germany,
pubmed-meshheading:19575222-Macrolides,
pubmed-meshheading:19575222-Nematoda,
pubmed-meshheading:19575222-Nematode Infections,
pubmed-meshheading:19575222-Parasite Egg Count,
pubmed-meshheading:19575222-Portugal,
pubmed-meshheading:19575222-Praziquantel,
pubmed-meshheading:19575222-Slovakia,
pubmed-meshheading:19575222-Tablets,
pubmed-meshheading:19575222-Treatment Outcome
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| pubmed:year |
2009
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| pubmed:articleTitle |
Field evaluation of the efficacy and safety of emodepside plus praziquantel tablets (Profender tablets for dogs) against naturally acquired nematode and cestode infections in dogs.
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| pubmed:affiliation |
Bayer Animal Health GmbH, Leverkusen, Germany. gertraut.altreuther@bayerhealthcare.com
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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