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rdf:type |
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lifeskim:mentions |
umls-concept:C0027627,
umls-concept:C0030552,
umls-concept:C0037949,
umls-concept:C0087111,
umls-concept:C0205421,
umls-concept:C0332162,
umls-concept:C0728940,
umls-concept:C1517004,
umls-concept:C1517927,
umls-concept:C1522673,
umls-concept:C1705822,
umls-concept:C2347423
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2009-7-3
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|
pubmed:abstractText |
The optimal management of spinal column metastatic disease is controversial. Local chemotherapy delivery systems allow targeted high-dose adjuvant therapy. We evaluated whether injection of OncoGel paclitaxel-releasing biodegradable polymer (Protherics, Inc., West Valley City, UT) into the tumor resection cavity at the time of surgery would improve the efficacy of surgical resection with or without external beam radiotherapy (XRT) in a rat model of spinal column metastases.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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|
pubmed:issn |
1524-4040
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
65
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-9; discussion 199-200
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pubmed:meshHeading |
pubmed-meshheading:19574842-Animals,
pubmed-meshheading:19574842-Breast Neoplasms,
pubmed-meshheading:19574842-Cell Line, Tumor,
pubmed-meshheading:19574842-Combined Modality Therapy,
pubmed-meshheading:19574842-Disease Models, Animal,
pubmed-meshheading:19574842-Drug Delivery Systems,
pubmed-meshheading:19574842-Female,
pubmed-meshheading:19574842-Hindlimb,
pubmed-meshheading:19574842-Neoplasm Transplantation,
pubmed-meshheading:19574842-Neurologic Examination,
pubmed-meshheading:19574842-Paclitaxel,
pubmed-meshheading:19574842-Radiotherapy, Adjuvant,
pubmed-meshheading:19574842-Rats,
pubmed-meshheading:19574842-Rats, Inbred F344,
pubmed-meshheading:19574842-Spinal Neoplasms,
pubmed-meshheading:19574842-Statistics, Nonparametric,
pubmed-meshheading:19574842-Time Factors
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|
pubmed:year |
2009
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pubmed:articleTitle |
Adjuvant treatment with locally delivered OncoGel delays the onset of paresis after surgical resection of experimental spinal column metastasis.
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pubmed:affiliation |
Department of Neurosurgery, The Johns Hopkins University, Baltimore, Maryland, USA.
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pubmed:publicationType |
Journal Article
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