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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2009-8-20
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pubmed:abstractText |
We previously reported that interferons (IFNs) regulate transcription of HIF-1alpha in human endothelial cells (ECs), linking immunity and hypoxia. Prolyl hydroxylases (PHDs) regulate expression of HIF-1alpha in response to hypoxia. We examined whether IFNs affect PHD expression and whether PHDs regulate the EC response to IFNs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids, Dicarboxylic,
http://linkedlifedata.com/resource/pubmed/chemical/Deferoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/Dioxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/EGLN3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Janus Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/oxalylglycine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1363-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:19574556-Amino Acids, Dicarboxylic,
pubmed-meshheading:19574556-Cell Hypoxia,
pubmed-meshheading:19574556-Cells, Cultured,
pubmed-meshheading:19574556-Deferoxamine,
pubmed-meshheading:19574556-Dioxygenases,
pubmed-meshheading:19574556-Endothelial Cells,
pubmed-meshheading:19574556-Enzyme Induction,
pubmed-meshheading:19574556-Enzyme Inhibitors,
pubmed-meshheading:19574556-Genes, Immediate-Early,
pubmed-meshheading:19574556-Humans,
pubmed-meshheading:19574556-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19574556-Interferon-alpha,
pubmed-meshheading:19574556-Interferon-gamma,
pubmed-meshheading:19574556-Janus Kinases,
pubmed-meshheading:19574556-RNA, Messenger,
pubmed-meshheading:19574556-RNA Interference,
pubmed-meshheading:19574556-STAT1 Transcription Factor,
pubmed-meshheading:19574556-Signal Transduction,
pubmed-meshheading:19574556-Time Factors,
pubmed-meshheading:19574556-Transcription, Genetic
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pubmed:year |
2009
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pubmed:articleTitle |
Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells.
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pubmed:affiliation |
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8089 , USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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