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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2009-8-4
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pubmed:abstractText |
RNA-binding proteins (RBPs) and microRNAs (miRNAs) are potent post-transcriptional regulators of gene expression. Here, we show that the RBP HuR reduced c-Myc expression by associating with the c-Myc 3' untranslated region (UTR) next to a miRNA let-7-binding site. Lowering HuR or let-7 levels relieved the translational repression of c-Myc. Unexpectedly, HuR and let-7 repressed c-Myc through an interdependent mechanism, as let-7 required HuR to reduce c-Myc expression and HuR required let-7 to inhibit c-Myc expression. Our findings suggest a regulatory paradigm wherein HuR inhibits c-Myc expression by recruiting let-7-loaded RISC (RNA miRNA-induced silencing complex) to the c-Myc 3'UTR.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-11289308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-12464637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-12546792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-14981256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-15284456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-15372042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-15766526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-15914670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-16141059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-16651716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-16777595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-16914445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-17114943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-17132932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-17572691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-17942906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18073770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18177264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18197166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18365017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18581050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18593881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-18927508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-19165215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-19167326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-8497264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-8907704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19574298-9692549
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Argonaute Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EIF2C2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ELAVL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-2,
http://linkedlifedata.com/resource/pubmed/chemical/MYC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MicroRNAs,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Induced Silencing Complex,
http://linkedlifedata.com/resource/pubmed/chemical/mirnlet7 microRNA, human
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1549-5477
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1743-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19574298-3' Untranslated Regions,
pubmed-meshheading:19574298-Antigens, Surface,
pubmed-meshheading:19574298-Argonaute Proteins,
pubmed-meshheading:19574298-Base Sequence,
pubmed-meshheading:19574298-Eukaryotic Initiation Factor-2,
pubmed-meshheading:19574298-Gene Expression Regulation,
pubmed-meshheading:19574298-HeLa Cells,
pubmed-meshheading:19574298-Humans,
pubmed-meshheading:19574298-MicroRNAs,
pubmed-meshheading:19574298-Molecular Sequence Data,
pubmed-meshheading:19574298-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:19574298-RNA, Messenger,
pubmed-meshheading:19574298-RNA-Binding Proteins,
pubmed-meshheading:19574298-RNA-Induced Silencing Complex
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pubmed:year |
2009
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pubmed:articleTitle |
HuR recruits let-7/RISC to repress c-Myc expression.
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pubmed:affiliation |
Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA. kimhye@grc.nia.nih.gov
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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