Linked Life Data

19573950

Source:http://linkedlifedata.com/resource/pubmed/id/19573950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2011-3-28
pubmed:abstractText
To determine whether polymorphisms in the microtubule-associated protein tau (MAPT) and/or glycogen synthase kinase-3? (GSK3?) genes underpin susceptibility to Parkinson's disease (PD), we conducted a case-control association study in a Greek cohort of 196 PD cases and 163 healthy controls. In our study, the MAPT H1 haplotype was found to be significantly associated with PD, no association was detected between the intronic rs6438552 (-157 T/C) GSK3? polymorphism and PD, whereas the C/C genotype of the promoter rs334558 (-50 T/C) GSK3? polymorphism was found to exert a protective role. The C/C genotype of the rs334558 GSK3? polymorphism was also found to have an additional protective role in our MAPT H1/H1 PD subgroup. Haplotype analysis revealed that, the T-T haplotype of both GSK3? polymorphisms was over-represented in PD patients compared to controls, and this association was independent of MAPT H1 haplotype.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1558-1497
pubmed:author
pubmed:copyrightInfo
Copyright © 2009 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546.e1-5
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
GSK3? polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort.
pubmed:affiliation
Department of General Biology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't