Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1991-12-31
|
| pubmed:abstractText |
The highly conserved DNA-binding domain of the steroid hormone receptors contains two 'zinc finger'-like sequence motifs. The three-dimensional structure in solution has been determined using two-dimensional 1H nuclear magnetic resonance (NMR) spectroscopy and shows that the two 'zinc finger'-like motifs fold to form a single structural domain. The combination of this structural information and mutagenesis data reveals how this family of transcriptional regulators bind to DNA.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0968-0004
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
291-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1957350-Amino Acid Sequence,
pubmed-meshheading:1957350-Animals,
pubmed-meshheading:1957350-Base Sequence,
pubmed-meshheading:1957350-Binding Sites,
pubmed-meshheading:1957350-DNA,
pubmed-meshheading:1957350-Models, Molecular,
pubmed-meshheading:1957350-Protein Conformation,
pubmed-meshheading:1957350-Receptors, Steroid,
pubmed-meshheading:1957350-Transcription, Genetic,
pubmed-meshheading:1957350-Zinc Fingers
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Beyond zinc fingers: steroid hormone receptors have a novel structural motif for DNA recognition.
|
| pubmed:affiliation |
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
|
| pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|