Linked Life Data

19572603

Source:http://linkedlifedata.com/resource/pubmed/id/19572603

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2009-9-3
pubmed:abstractText
Six antitumor antibiotics of a new structure class, indoxamycins A-F (1-6), were isolated from a saline culture group of marine-derived actinomyces whose strains showed approximately 96% sequence homology of 16S rDNA with the family streptomycetaceae. The structures of these indoxamycins, which are unusual polyketides composed of six consecutive chiral centers, were assigned by combined spectral and chemical methods. In feeding experiments using a stable isotope label, indoxamycin A was assembled from propionate units initially forming the "aglycon" pentamethyl indeno furan. The discovery of these unprecedented compounds from marine-derived actinomycetes, a low gene homology genus, offers a significant opportunity for drug discovery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1520-6904
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5502-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Indoxamycins A-F. Cytotoxic tricycklic polypropionates from a marine-derived actinomycete.
pubmed:affiliation
Central Research Laboratory, Nippon Suisan Kaisha, Ltd., 559-6 Kitano-machi Hachioji, Tokyo 192-0906, Japan. s-satou@nissui.co.jp
pubmed:publicationType
Journal Article