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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2011-4-7
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pubmed:abstractText |
Trastuzumab (Herceptin™) is often internalized following binding to Her2+ tumor cells. The objective of this study was to investigate whether trastuzumab can be used as a specific carrier to deliver antisense oligomers into Her2+ tumor cells both in vitro and in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Biotin,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholinos,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Streptavidin,
http://linkedlifedata.com/resource/pubmed/chemical/trastuzumab
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1619-7089
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1977-86
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19572130-Animals,
pubmed-meshheading:19572130-Antibodies, Monoclonal,
pubmed-meshheading:19572130-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:19572130-Biological Transport,
pubmed-meshheading:19572130-Biotin,
pubmed-meshheading:19572130-Breast Neoplasms,
pubmed-meshheading:19572130-Cell Line, Tumor,
pubmed-meshheading:19572130-Cell Transformation, Neoplastic,
pubmed-meshheading:19572130-Drug Carriers,
pubmed-meshheading:19572130-Female,
pubmed-meshheading:19572130-Humans,
pubmed-meshheading:19572130-Intracellular Space,
pubmed-meshheading:19572130-Mice,
pubmed-meshheading:19572130-Morpholines,
pubmed-meshheading:19572130-Morpholinos,
pubmed-meshheading:19572130-Nanoparticles,
pubmed-meshheading:19572130-Receptor, erbB-2,
pubmed-meshheading:19572130-Streptavidin
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pubmed:year |
2009
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pubmed:articleTitle |
Tumor delivery of antisense oligomer using trastuzumab within a streptavidin nanoparticle.
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pubmed:affiliation |
Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Yi.Wang@Yale.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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