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pubmed-article:19571598pubmed:abstractTextSleep-wake disturbance, frequently observed in major depressive disorder (MDD), negatively influences clinical status. Treatment with antidepressants also reportedly affects circadian rhythms. In a recent in vitro study, the nuclear receptor Rev-erbalpha was reported to be related to circadian rhythms, and was shown to be involved in the biological action of lithium therapy. Therefore, we examined the association between the orphan nuclear receptor Rev-erbalpha gene (NR1D1) and the efficacy of fluvoxamine treatment in 118 Japanese patients with major depressive disorder.lld:pubmed
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pubmed-article:19571598pubmed:copyrightInfoCopyright 2009 S. Karger AG, Basel.lld:pubmed
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pubmed-article:19571598pubmed:articleTitleOrphan nuclear receptor Rev-erb alpha gene (NR1D1) and fluvoxamine response in major depressive disorder in the Japanese population.lld:pubmed
pubmed-article:19571598pubmed:affiliationDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan. tarok@fujita-hu.ac.jplld:pubmed
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