Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1991-12-31
|
pubmed:abstractText |
There are now three methods to evaluate treatments of pneumocystosis: (1) the animal model, using adult rats under corticosteroids; the intensity of infection is assessed on pulmonary appositions and can then be evaluated after administration of a potential treatment compared with a reference; (2) the in vitro propagation of P. carinii observed from rat lung extracts cultured on cell lines; this method, however, is limited by the difficulties encountered in quantifying the parasitic types; (3) the inhibition by the drugs tested of enzymes involved in folate synthesis is a method that is still under evaluation. The animal model remains the reference method.
|
pubmed:language |
fre
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0761-8417
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
109-14
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1957102-Animals,
pubmed-meshheading:1957102-Cells, Cultured,
pubmed-meshheading:1957102-Clinical Trials as Topic,
pubmed-meshheading:1957102-Disease Models, Animal,
pubmed-meshheading:1957102-Folic Acid,
pubmed-meshheading:1957102-Humans,
pubmed-meshheading:1957102-Pneumocystis,
pubmed-meshheading:1957102-Pneumonia, Pneumocystis,
pubmed-meshheading:1957102-Rats,
pubmed-meshheading:1957102-Rats, Inbred Strains,
pubmed-meshheading:1957102-Trimethoprim-Sulfamethoxazole Combination
|
pubmed:year |
1991
|
pubmed:articleTitle |
[Treatment of pneumocystosis: preclinical evaluation].
|
pubmed:affiliation |
INSERM U 13, Hôpital Claude-Bernard, Paris.
|
pubmed:publicationType |
Journal Article,
English Abstract
|