Source:http://linkedlifedata.com/resource/pubmed/id/19570012
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-7-2
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| pubmed:abstractText |
Controlled release formations of drugs were prepared with matrix materials of the natural polysaccharides sodium alginate and +/--carrageenan. The drugs used were sodium salicylate (anionic) and lidocaine-HCl (cationic). The release characteristics of the drugs were studied under different pH and compositions of aqueous media. The cationic drug (lidocaine-HCl) was released more slowly than the anionic one (sodium salicylate) because of the negative charge of the matrices. The release from both sodium alginate and +/--carrageenan tablet was retarded in acidic medium. At the same pH of the medium, the release into buffer solutions (containing metallic cations Na(+) and K(+), respectively) was slower than into HC1 solution.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
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| pubmed:issn |
1071-7544
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
5
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
13-8
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| pubmed:year |
1998
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| pubmed:articleTitle |
Effect of pH on drug release from polysaccharide tablets.
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| pubmed:affiliation |
Department of Chemical Engineering, College of Engineering and Bioproducts Research Center, Yonsei University, Seoul, Korea.
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| pubmed:publicationType |
Journal Article
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